A heavy nucleus can contain hundreds of nucleons which means that with some approximation it can be treated as a classical system, rather than a quantum-mechanical one. In the resulting liquid-drop model, the nucleus has an energy which arises partly from surface tension and partly from electrical repulsion of the protons. The liquid-drop model is able to reproduce many features of nuclei, including the general trend of binding energy with respect to mass number, as well as the phenomenon of nuclear fission.
Superimposed on this classical picture, however, are quantum-mechanical effects, which can be described using the nuclear shell model, developed in large part by Maria Goeppert-Mayer. Nuclei with certain numbers of neutrons and protons (the magic numbers 2, 8, 20, 50, 82, 126, ...) are particularly stable, because their shells are filled.
Other more complicated models for the nucleus have also been proposed, such as the interacting boson model, in which pairs of neutrons and protons interact as bosons, analogously to Cooper pairs of electrons.
Much of current research in nuclear physics relates to the study of nuclei under extreme conditions such as high spin and excitation energy. Nuclei may also have extreme shapes (similar to that of Rugby balls) or extreme neutron-to-proton ratios. Experimenters can create such nuclei using artificially induced fusion or nucleon transfer reactions, employing ion beams from an accelerator. Beams with even higher energies can be used to create nuclei at very high temperatures, and there are signs that these experiments have produced a phase transition from normal nuclear matter to a new state, the quark-gluon plasma, in which the quarks mingle with one another, rather than being segregated in triplets as they are in neutrons and protons.